2016 Fiscal Year Final Research Report
Imaging of neural inputs to the mouse visual cortex under top-down attention
Project/Area Number |
25871135
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
Experimental psychology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Yoshida Takamasa 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (50525904)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Keywords | トップダウン型注意 / 視覚的注意 / 頭部固定型課題 / マウス視覚野 / 皮質ネットワーク / カルシウムイメージング / 全脳広域イメージング |
Outline of Final Research Achievements |
Although it is thought that attentional top-down signal from higher-order cortices regulates neural activity in the visual cortex, there has been no direct evidence. In this study, I have planned, firstly, to develop a visual attention task system using head-restricted mice and, secondly, to capture top-down input signal as calcium signal at the axon terminals using two-photon microscopy. However, some studies that introduced the similar concept were published after starting this study. The latter part was changed into development of a wide-field calcium imaging system in order to improve the achievement level of the goal. As a result, the cortex-wide imaging suggested a mechanism of multisensory integration involving attention in the association cortices.
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Free Research Field |
神経科学
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