2014 Fiscal Year Final Research Report
Functional acquirement of long noncoding RNA is regulated by alternative 3' end processing
| Project/Area Number |
25871195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Molecular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 非コードRNA / RNA結合タンパク質 / 選択的3'末端プロセシング |
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| Outline of Final Research Achievements |
To be aimed at elucidating the production mechanism of diverse functions of lncRNA, we explored how the alternative 3’ end processing of NEAT1 lncRNA is acted and regulated. HNRNPK, which is a factor of the alternative 3’ end processing of NEAT1 lncRNA, was focused and we discovered the multiple interaction factors that modulate the function for the processing of HNRNPK. In addition, we showed the great potential that the alternative 3’ end processing of NEAT1 lncRNA was modulated by JNK pathway, which is one of MAPK pathways.
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| Free Research Field |
分子生物学
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