The contribution of chromosomal structure and DNA damage to IgH-BCL2 chromosomal translocation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893027
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Gunma University
• Principal Investigator: YAMANE ARITO 群馬大学, 医学(系)研究科(研究院), 講師 (10420192)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: がんの発生

Outline of Final Research Achievements

Follicular lymphomas are second frequent occurring malignant lymphoma in the world. More than ninety percent of cases have the same recurrent chromosomal translocation between IgH and BCL2 loci. To elucidate mechanism of generation of IgH-BCL2 translocation, we used Next generation sequencing technologies to observe interaction of genome-wide loci and DNA damage throughout the genome.
IgH locus and BCL2 locus were not most frequent interacting loci in the mouse Pro-B cells in which the translocation is believed to occur. The result suggests the contribution of DNA damage is most important factor. The cause of DNA damage is remain to be elucidated in future studies.

Free Research Field

血液内科