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2014 Fiscal Year Final Research Report

C/EBP-alpha protects lung epithelial cells during CS-induced lung injury

Research Project

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Project/Area Number 25893106
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

SATO ATSUYASU  京都大学, 医学(系)研究科(研究院), 助教 (30706677)

Project Period (FY) 2013-08-30 – 2015-03-31
KeywordsC/EBPα / 喫煙 / 再生
Outline of Final Research Achievements

Alveolar type 2 cells are critical for lung homeostasis including regeneration after lung injury. In the present study, regeneration process was evaluated using isolated alveolar type 2 cells. The proliferation and differentiation of alveolar type 2 cells were shown by FACS based methods and lineage trace murine model. C/EBP-alpha, epithelial specific transcription factor, was specifically knocked down in lung epithelial cells. Using this model, the protective function of C/EBP-alpha against cigarette smoke stimulation was shown

Free Research Field

呼吸器内科

URL: 

Published: 2016-06-03  

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