A study on the role of the spleen in liver carcinogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893156
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: SAITO Yu 徳島大学, ヘルスバイオサイエンス研究部, 助教 (50548675)
• Research Collaborator: IMURA Satoru 徳島大学, 病院, 特任教授 (90380021) ; MORINE Yuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (60398021) ; IKEMOTO Tetsuya 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20398019)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 肝細胞癌 / 脾摘 / HGF / c-Met

Outline of Final Research Achievements

In Cirrhotic patients, the expressions of TGF-β1 derived from splenic macrophage in were significantly higher than those in normal liver patients. In addition, the splenic IL6, TNF-a, and MCP-1 expressions were lower and HGF expressions were higher. In the patients with splenectomy accompanied with liver cancer, the splenic IL-6, HGF and IL-8 expressions were significantly higher than those in the patients with splenectomy accompanied without liver cancer. Hepatic c-Met, the receptor of HGF, expression were also higher.
The relationship between spleen and liver had a critical role in liver fibrosis and carcinogenesis.

Free Research Field

消化器外科