The effect of adrenomedullin on Th17 cells in periodontal disease.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893158
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontology
• Research Institution: The University of Tokushima
• Principal Investigator: HOSOKAWA Ikuko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (50707908)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 歯周炎 / Th1 / Adrenomedullin / 繊維芽細胞

Outline of Final Research Achievements

We examined the effect of adrenomedullin (AM) on CXCL10, which is related with Th1 cells migration, production from TNF-α-stimulated human gingival fibroblasts (HGFs) in this study. We found that AM could inhibit CXCL10 production from TNF-α-stimulated HGFs. Therefore, AM could decrase the number of Th1 cells in periodontal lesion to inhibit CXCL10 production from HGFs. These results might explain that we might use AM for periodontal disease treatment because AM could inhibit inflammatory mediator expression, such as CXCL10, from periodontal resident cells.

Free Research Field

歯周治療系歯学