2014 Fiscal Year Final Research Report
To develope a novel screening method of histone deacetylase (HDAC) inhibitor having anticancer activity
| Project/Area Number |
25893215
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
FUJII SEIKO 九州歯科大学, 歯学部, 助教 (80714659)
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Keywords | HDAC阻害剤 / 口腔癌 / テロメラ―ゼ |
|---|
| Outline of Final Research Achievements |
Epigenetic modifications such as histone deacetylation are commonly related to tumor development and histone deacetylase (HDAC) inhibitors have been shown to be potential drugs for cancer treatment. Ky-2 is a novel HDAC inhibitor produced by a combination of the HDAC inhibitors TSA and TPX.
In the present study, we investigated the effectiveness of Ky-2 to induce cell cycle and apoptosis in oral squamous carcinoma cells. In addition, we examined the signaling pathway related to the cell cycle and apoptosis in Ky-2-treated oral squamous carcinoma cells.
|
| Free Research Field |
医歯薬学
|
