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2014 Fiscal Year Final Research Report

Establishment of novel periodontal tissue regeneration using mesenchymal stem cells with high osteodifferentiation capacity

Research Project

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Project/Area Number 25893221
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontology
Research InstitutionKansai Medical University (2014)
Iwate Medical University (2013)

Principal Investigator

SAWADA Shunsuke  関西医科大学, 医学部, 助教 (60711075)

Project Period (FY) 2013-08-30 – 2015-03-31
KeywordsMSC / サイトカイン / 歯周病 / IL-1 / IL-6 / 再生医学 / 間葉系幹細胞
Outline of Final Research Achievements

Chronic periodontitis is an intraoral infectious disease that affects the nation with high prevalence. We see a lot of patients being forced to extract their teeth because of inflammatory bone resorption. To promote fundamental research of novel cell therapy using mesencymal stem cells, we established stem cell lines from the bone marrow of GFP transgenic mice and constructed a new expression vector targeting inhibition of several inflammatory cytokines. We expect that those new tools promote novel cell therapy in periodontal research.

Free Research Field

歯周治療系歯学

URL: 

Published: 2016-06-03  

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