2013 Fiscal Year Final Research Report
Temporal imaging of epileptic activity in animal models
| Project/Area Number |
25893266
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Soka University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2014-03-31
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| Keywords | てんかんモデル / 内因性信号 / キンドリング / 脳血流画像 |
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| Research Abstract |
In this study, we measured the alteration of cerebral blood flow (CBF) during epileptiform seizure induced by acute kindling and drug injection of the mouse and rat hippocampus to reveal the progression of epileptic activity. In consequence, we found cingulate gyrus might mediate propagation of epileptiform seizure for motor cortex. Additionally, it was confirmed alteration of CBF during epileptiform seizure occured bilaterally. It was suggested that metaboric change caused by epileptiform seizure might occur bilaterally and accompany change of local filed potentials.
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