2014 Fiscal Year Final Research Report
Effect of suspended particulate matter (e.g., PM2.5, etc.) on type 1 diabetes
| Project/Area Number |
25893285
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene and public health
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 浮遊粒子状物質 / 糖尿病 / 免疫学 / 黄砂 |
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| Outline of Final Research Achievements |
Patients with type 1 diabetes are currently increasing, and environmental factors are thought to be one of its causes. Asian sand dust (ASD) is the suspended particulate matter. The events of ASD flying to Japan are increasing since 2000. Although ASD is designated as one of reference materials for air quality to protect public health, it is still unclear whether ASD can become the environmental factor of diabetes onset. In this study, we examined the effect of ASD on type 1 diabetes by using two systems of type 1 diabetes model mice with different pathogenesis. As a result, it was suggested that ASD may become either the exacerbating factor or suppressor for the diabetes onset depending on the system of the type 1 diabetes model mice. However, it is unknown what kind of mechanisms cause such conflicting results. Therefore, further examinations are required.
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| Free Research Field |
免疫学
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