Study of coagulation and thrombogenic system via the coagulation factor and the its new receptor.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893300
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUJITA YOSHIKO 独立行政法人国立循環器病研究センター, 研究所, 研究員 (30416218)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 血管 / 血液

Outline of Final Research Achievements

The purpose of this study is to elucidate the new mechanism of blood coagulation system. In this study, the interaction of coagulation factor A and the its new receptor B caused acceleration of thrombin production and blood coagulation by the serial measurement of thrombin activation in normal human plasma and reconstitution system.
We have unraveled the new mechanism which accelerates the activation of coagulation system. It was a chance to rethink of the physiological and pathophysiological mechanism of hemostasis-thrombus-coagulation. We expect that this study will find the resolution key to pathological coagulation thrombus.

Free Research Field

薬理学