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2017 Fiscal Year Annual Research Report

System construction and the effect verification of the population approach for dementia prevention

Research Project

Project/Area Number 26242059
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

島田 裕之  国立研究開発法人国立長寿医療研究センター, 予防老年学研究部, 部長 (00370974)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords活動 / 高齢者 / プロペンシティスコア / ポピュレーション / 要介護認定
Outline of Annual Research Achievements

本研究は、高齢者の活動の促進によって認知症予防を目指すポピュレーション・アプローチのシステムの構築と効果検証を行うため、自治体、企業、住民と共同して研究を推進した。対象とした自治体は、愛知県高浜市(人口46,000名、高齢化率17%)である。平成29年度は、高齢者機能健診受診者4,122(女性:2,319名、男性:1,803名、平均年齢:71.4歳)名の活動量データ収集を、高浜市内の98か所の健康自生地に活動量計データ収集端末を設置して行った。なお、健康自生地とは高浜市が認定した高齢者が集うことのできる場所やサービスである。1年間で10か月以上の活動データが収集できた群(活動実施群)と一度も収集できなかった群(活動非実施群)をプロペンシティスコアマッチングにて属性を調整した集団を作り(両群ともに1106名)、1年間の要介護認定発生について比較をした。対象者は2212名(女性:1225名、男性:987名、平均年齢:71.3歳)であった。両群に年齢、性別、現病歴(心疾患、呼吸器疾患、脳卒中、うつ病、パーキンソン病、高血圧、糖尿病、脂質異常症、変形性関節症)、服薬数、日常生活動作、歩行速度、mini-mental state examination、geriatric depression scaleにおける有意差は認められなかった。1年間の追跡期間中に24名(1.1%)の対象者が要介護認定を受けた。Cox比例ハザードモデルにより活動の実施と要介護認定の発生との関係を調べた結果、活動非実施群に比較して実施群では要介護発生のハザード比が0.14(95%信頼区間:0.04-0.48)であった。以上の結果から、日常的に活動を実施することは要介護の発生を回避するための手段になり得ると考えられた。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

  • Research Products

    (38 results)

All 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (6 results) Remarks (1 results)

  • [Int'l Joint Research] 国立シンガポール大学(シンガポール)

    • Country Name
      SINGAPORE
    • Counterpart Institution
      国立シンガポール大学
  • [Int'l Joint Research] アインシュタイン医科大学(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      アインシュタイン医科大学
  • [Int'l Joint Research] 東亜大学(韓国)

    • Country Name
      KOREA (REP. OF KOREA)
    • Counterpart Institution
      東亜大学
  • [Journal Article] Cognitive Frailty and Incidence of Dementia in Older Persons.2018

    • Author(s)
      Shimada H, Makizako H, Tsutsumimoto K, Doi T, Lee S, Suzuki T.
    • Journal Title

      J Prev Alzheimers Dis

      Volume: 5 Pages: 42-48

    • DOI

      10.14283/jpad.2017.29.

    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Driving Skill Training on Safe Driving in Older Adults with Mild Cognitive Impairment.2018

    • Author(s)
      Shimada H, Hotta R, Makizako H, Doi T, Tsutsumimoto K, Nakakubo S, Makino K.
    • Journal Title

      Gerontology

      Pages: Epub

    • DOI

      10.1159/000487759.

    • Peer Reviewed
  • [Journal Article] Healthy Behaviors and Incidence of Disability in Community-Dwelling Elderly.2018

    • Author(s)
      Hotta R, Makizako H, Doi T, Tsutsumimoto K, Nakakubo S, Makino K, Suzuki T, Shimada H1.
    • Journal Title

      Am J Health Behav

      Volume: 42 Pages: 51-58

    • DOI

      10.5993/AJHB.42.1.5.

    • Peer Reviewed
  • [Journal Article] Behavioral protective factors of increased depressive symptoms in community-dwelling older adults: A prospective cohort study.2018

    • Author(s)
      Uemura K, Makizako H, Lee S, Doi T, Lee S, Tsutsumimoto K, Shimada H.
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 33 Pages: e234-e241

    • DOI

      10.1002/gps.4776.

    • Peer Reviewed
  • [Journal Article] Relationship between chronic kidney disease without diabetes mellitus and components of frailty in community-dwelling Japanese older adults.2018

    • Author(s)
      Lee S, Lee S, Bae S, Harada K, Jung S, Imaoka M, Makizako H, Doi T, Shimada H.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Pages: 286-292

    • DOI

      10.1111/ggi.13180.

    • Peer Reviewed
  • [Journal Article] Relationship between physical activity levels and depressive symptoms in community-dwelling older Japanese adults.2018

    • Author(s)
      Jung S, Lee S, Lee S, Bae S, Imaoka M, Harada K, Shimada H.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 18 Pages: 421-427

    • DOI

      10.1111/ggi.13195.

    • Peer Reviewed
  • [Journal Article] Social Frailty Leads to the Development of Physical Frailty among Physically Non-Frail Adults: A Four-Year Follow-Up Longitudinal Cohort Study.2018

    • Author(s)
      Makizako H, Shimada H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Makino K, Lee S.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 15 Pages: pii: E490

    • DOI

      10.3390/ijerph15030490.

    • Peer Reviewed
  • [Journal Article] The impact of sarcopenia on incident homebound status among community-dwelling older adults: A prospective cohort study2018

    • Author(s)
      Uemura K, Makizako H, Lee S, Doi T, Lee S, Tsutsumimoto K, Shimada H
    • Journal Title

      Maturitas

      Volume: 113 Pages: 26-31

    • DOI

      10.1016/j.maturitas.2018.03.007

    • Peer Reviewed
  • [Journal Article] Long and short sleep duration and physical frailty in community-dwelling older adults2018

    • Author(s)
      Nakakubo S, Makizako H, Doi T, Tsutsumimoto K, Hotta R, Lee S, Lee S, Bae S, Makino K, Suzuki T, Shimada H
    • Journal Title

      J Nutr Health Aging

      Pages: Epub

    • Peer Reviewed
  • [Journal Article] Associations of Near-Miss Traffic Incidents with Attention and Executive Function among Older Japanese Drivers2018

    • Author(s)
      Makizako H, Shimada H, Hotta R, Doi T, Tsutsumimoto K, NakakuboS, Makino K
    • Journal Title

      Geriatrics & Gerontology International

      Pages: Epub

    • Peer Reviewed
  • [Journal Article] Cognitive function and unsafe driving acts during an on-road test among community-dwelling older adults with cognitive impairments2018

    • Author(s)
      Hotta R, Makizako H, Doi T, Tsutsumimoto K, Nakakubo S, Makino K, Shimada H
    • Journal Title

      Geriatrics & Gerontology International

      Pages: Epub

    • Peer Reviewed
  • [Journal Article] Effects of exercise on brain activity during walking in older adults: a randomized controlled trial2017

    • Author(s)
      Shimada Hiroyuki、Ishii Kenji、Makizako Hyuma、Ishiwata Kiichi、Oda Keiichi、Suzukawa Megumi
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation

      Volume: 14

    • DOI

      10.1186/s12984-017-0263-9

    • Peer Reviewed
  • [Journal Article] Conversion and Reversion Rates in Japanese Older People With Mild Cognitive Impairment2017

    • Author(s)
      Shimada Hiroyuki、Makizako Hyuma、Doi Takehiko、Lee SungChul、Lee Sangyoon
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 18 Pages: 808.e1~808.e6

    • DOI

      10.1016/j.jamda.2017.05.017

    • Peer Reviewed
  • [Journal Article] Effects of Combined Physical and Cognitive Exercises on Cognition and Mobility in Patients With Mild Cognitive Impairment: A Randomized Clinical Trial.2017

    • Author(s)
      Shimada H, Makizako H, Doi T, Park H, Tsutsumimoto K, Verghese J, Suzuki T.
    • Journal Title

      J Am Med Dir Assoc

      Pages: S1525-8610

    • DOI

      10.1016/j.jamda.2017.09.019.

    • Peer Reviewed
  • [Journal Article] The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction.2017

    • Author(s)
      Umegaki H, Makino T, Uemura K, Shimada H, Hayashi T, Cheng XW, Kuzuya M.
    • Journal Title

      Front Aging Neurosci

      Volume: 23 Pages: 72

    • DOI

      10.3389/fnagi.2017.00072.

    • Peer Reviewed
  • [Journal Article] The association between anorexia of aging and physical frailty: Results from the national center for geriatrics and gerontology's study of geriatric syndromes.2017

    • Author(s)
      Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H.
    • Journal Title

      Maturitas

      Volume: 97 Pages: 32-37

    • DOI

      10.1016/j.maturitas.2016.12.005.

    • Peer Reviewed
  • [Journal Article] Objectively-measured outdoor time and physical and psychological function among older adults.2017

    • Author(s)
      Harada K, Lee S, Lee S, Bae S, Harada K, Suzuki T, Shimada H.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Pages: 1455-1462

    • DOI

      10.1111/ggi.12895.

    • Peer Reviewed
  • [Journal Article] Predictors of self-reported knee osteoarthritis in community-dwelling older women in Japan: A cross-sectional and longitudinal cohort study.2017

    • Author(s)
      Kojima N, Kim M, Saito K, Yoshida Y, Hirano H, Obuchi S, Shimada H, Suzuki T, Kim H.
    • Journal Title

      Arch Gerontol Geriatr.

      Volume: 73 Pages: 125-132

    • DOI

      10.1016/j.archger.2017.07.005.

    • Peer Reviewed
  • [Journal Article] Impact of poor sleep quality and physical inactivity on cognitive function in community-dwelling older adults2017

    • Author(s)
      Nakakubo S, Makizako H, Doi T, Tsutsumimoto K, Lee S, Lee S, Hotta R, Bae S, Suzuki T, Shimada H.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Pages: 1823-1828

    • DOI

      10.1111/ggi.12973.

    • Peer Reviewed
  • [Journal Article] Association between body composition parameters and risk of mild cognitive impairment in older Japanese adults.2017

    • Author(s)
      Bae S, Shimada H, Park H, Lee S, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Pages: 2053-2059

    • DOI

      10.1111/ggi.13018.

    • Peer Reviewed
  • [Journal Article] The Relationships Between Components of Metabolic Syndrome and Mild Cognitive Impairment Subtypes: A Cross-Sectional Study of Japanese Older Adults.2017

    • Author(s)
      Bae S, Shimada H, Lee S, Makizako H, Lee S, Harada K, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T.
    • Journal Title

      J Alzheimers Dis

      Volume: 60 Pages: 913-921

    • DOI

      10.3233/JAD-161230.

    • Peer Reviewed
  • [Journal Article] Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability.2017

    • Author(s)
      Doi T, Shimada H, Makizako H, Tsutsumimoto K, Verghese J, Suzuki T.
    • Journal Title

      J Alzheimers Dis

      Volume: 59 Pages: 77-84

    • DOI

      10.3233/JAD-170195.

    • Peer Reviewed
  • [Journal Article] Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People.2017

    • Author(s)
      Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H.
    • Journal Title

      J Am Med Dir Assoc

      Volume: 18 Pages: 603-607

    • DOI

      10.1016/j.jamda.2017.02.004.

    • Peer Reviewed
  • [Presentation] 認知症のより良いケアと予防のために 身体および認知的フレイルの予防方法の開発と効果検証2018

    • Author(s)
      島田裕之
    • Organizer
      平成29年度 脳とこころの研究 第三回公開シンポジウム
    • Invited
  • [Presentation] Cognitive Frailty and Incidence of Dementia in Older Persons2017

    • Author(s)
      Shimada H, Makizako H, Tsutsumimoto K, Doi T, Lee S, Suzuki T
    • Organizer
      Alzheimer’s Association International Conference 2017
    • Int'l Joint Research
  • [Presentation] Prevalence and prognosis of cognitive frailty2017

    • Author(s)
      Shimada H
    • Organizer
      The 3rd NCGG-ICAH Symposium
    • Int'l Joint Research / Invited
  • [Presentation] A New Non-Pharmacological Intervention Scheme for Physical and Cognitive Frailty in the Community.2017

    • Author(s)
      Shimada H, Lee S, Doi T
    • Organizer
      3rd Asian Conference for Frailty and Sarcopenia
    • Int'l Joint Research / Invited
  • [Presentation] 認知症・アルツハイマー病に対する運動の作用メカニズムと予防のエンビデンス2017

    • Author(s)
      島田裕之
    • Organizer
      第36回日本認知症学会学術集会
    • Invited
  • [Book] パーソン・センタード・ケアでひらく認知症看護の扉2018

    • Author(s)
      鈴木 みずえ、酒井 郁子
    • Total Pages
      344
    • Publisher
      南江堂
    • ISBN
      4524255141
  • [Book] 脳卒中に対する標準的理学療法介入―何を考え、どう進めるか?2017

    • Author(s)
      潮見 泰藏 (編集)
    • Total Pages
      385
    • Publisher
      文光堂
    • ISBN
      978-4830645495
  • [Book] 認知症予防専門士テキストブック 改訂版2017

    • Author(s)
      日本認知症予防学会、浦上克哉、川瀬康裕
    • Total Pages
      388
    • Publisher
      メディア・ケアプラス
    • ISBN
      4198645035
  • [Book] エビデンスに基づく理学療法クイックリファレンス2017

    • Author(s)
      内山靖
    • Total Pages
      189
    • Publisher
      医歯薬出版
    • ISBN
      978-4-263-21673-6
  • [Book] 認知症者の転倒予防とリスクマネジメント2017

    • Author(s)
      原田 敦、日本転倒予防学会、武藤 芳照、鈴木 みずえ
    • Total Pages
      408
    • Publisher
      日本医事新報社
    • ISBN
      4784961798
  • [Book] サルコペニア診療ガイドライン20172017

    • Author(s)
      サルコペニア診療ガイドライン作成委員会
    • Total Pages
      82
    • Publisher
      ライフサイエンス出版
    • ISBN
      978-4-89775-365-2
  • [Remarks] 予防老年学研究部

    • URL

      http://www.ncgg.go.jp/cgss/department/cre/index.html

URL: 

Published: 2018-12-17   Modified: 2022-02-28  

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