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2017 Fiscal Year Final Research Report

CRISPR-mediated reading and writing of the epigenome

Research Project

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Project/Area Number 26250038
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Genome biology
Research InstitutionKyushu University

Principal Investigator

Ito Takashi  九州大学, 医学研究院, 教授 (90201326)

Research Collaborator MIURA Fumihito  九州大学, 大学院医学研究院, 講師 (50447348)
OKADA Satoshi  九州大学, 大学院医学研究院, 助教 (30734488)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsエピゲノム / ゲノム編集 / 次世代シーケンシング / CRISPR/Cas9 / dCas9 / DNAメチル化 / BiFC
Outline of Final Research Achievements

The cell responds to environmental changes by altering its genome expression pattern, but not the genome sequences per se, and inherits the pattern even after cell division. This mechanism is called epigenetics, which is based on various chemical modifications of DNA and proteins comprising the chromosomes, and the term epigenome indicates the genome-wide pattern of these epigenetic modifications. It becomes increasingly possible to read, write, and visualize the epigenetics of targeted genomic regions by combining the technologies of CRISPR/Cas9-based genome editing and the next-generation DNA sequencing. In this study, we have developed basic methods for these novel approaches in epigenomics.

Free Research Field

ゲノム科学

URL: 

Published: 2019-03-29  

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