Chemical biology of cyanide-insensitive Trypanosome alternative oxidase.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26253025
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Nagasaki University (2016); The University of Tokyo (2014-2015)
• Principal Investigator: KITA Kiyoshi 長崎大学, 熱帯医学・グローバルヘルス研究科, 教授 (90134444)
• Co-Investigator(Kenkyū-buntansha): 稲岡 健ダニエル 東京大学, 医学(系)研究科(研究院), 助教 (10623803)
• Co-Investigator(Renkei-kenkyūsha): HARADA Shigeharu 京都工芸繊維大学, 工芸科学研究科, 教授 (80156504) ; SAIMOTO Hiroyuki 鳥取大学, 工学研究科, 教授 (20186977)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: シアン耐性酸化酵素 / トリパノソーマ / アスコフラノン / 生合成

Outline of Final Research Achievements

We have shown the parasite energy metabolism enzymes has extremely special properties and plays an important role in adaptation in the host. Trypanosome alternative oxidase is essential for the growth of African trypanosome inhabiting the host's bloodstream and is a promising enzyme as a drug target.
We focused on the specific inhibitor ascofuranone which we discovered. Characteristics of the enzyme, its interaction with inhibitors and biosynthesis of ascofuranone have been studied from a standpoint of chemical biology which includes chemical approaches as well as general biology and keeps mind application.

Free Research Field

寄生虫学(含衛生動物学)