Epigenome analysis in cardiomyocyte differentiation and failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 26253049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Komuro Issei 東京大学, 医学部附属病院, 教授 (30260483)
• Co-Investigator(Kenkyū-buntansha): 内藤 篤彦 東京大学, 医学部附属病院, 助教 (10588891) ; 野村 征太郎 東京大学, 医学部附属病院, 助教 (10722118)
• Co-Investigator(Renkei-kenkyūsha): NOMURA Seitaro 東京大学, 医学部附属病院, 特任助教 (10722118)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分子心臓学 / エピゲノム / 遺伝子制御

Outline of Final Research Achievements

We analyzed epigenomic regulation of cardiomyocyte differentiation and heart failure. Genome-wide enhancer analysis revealed that β-catenin, which is activated by Wnt signaling upon differentiation, forms a complex with epigenomic regulators to activate mesodermal enhancers and provokes the down-stream gene program. Through integrative analysis of single-cell transcriptomes and epigenomes, we also unveiled that transcription factors which are induced upon pressure overload activates enhancers regulating the heart failure gene program. These results indicate that the epigenome regulates cardiomyocyte differentiation and failure.

Free Research Field

循環器内科