Identification and analyses on inductive pathway in impairment of memory and learning caused by chronic intake of high fat diet

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: National Center for Geriatrics and Gerontology (2015-2016); University of Miyazaki (2014)
• Principal Investigator: TAGUCHI Akiko 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 部長 (80517186)
• Co-Investigator(Kenkyū-buntansha): 上野 浩晶 宮崎大学, 医学部, 助教 (00381062) ; 望月 仁志 宮崎大学, 医学部, 講師 (50501699) ; 塩見 一剛 宮崎大学, 医学部, 准教授 (40305082)
• Research Collaborator: YAMAMOTO Yasuhiro ; FUKUOKAYA Wataru ; KAWABE Kenshiro ; KURATA Eiko ; KASHIWADA Mana ; SAJI Tamiko
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病 / 記憶学習能 / インスリンシグナル / 老化 / 血中因子 / 体系的記憶学習調節機構 / 交換輸血 / パラバイオーシス

Outline of Final Research Achievements

Our previous study suggested that brain insulin signaling is involved in the regulation of memory and learning. In the preset study, we show that DIO mice , a potential model animals of pre- dementia with diabetes, in which impairment of memory and learning was accompanied by altered brain insulin signaling. Here, using exchange blood transfusion and heterochronic parabiosis between DIO mice and WT mice, we found that decline in memory and learning in DIO mice may be associated with diabetes-induced blood-borne factors, and then identified several blood factors through protein array system. Moreover, our data also indicate that one of those interacts with brain insulin signaling, and its related drugs affect memory and learning in DIO mice.

Free Research Field

複合領域