Mutual central-peripheral interaction in cooperation among sleep, exercise and metabolism

2017 Fiscal Year Final Research Report

• Project/Area Number: 26282193
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: SEI Hiroyoshi 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (40206602)
• Co-Investigator(Kenkyū-buntansha): 近久 幸子 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (00452649)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 睡眠 / 運動 / 代謝 / ケトン体 / 脳 / 肝臓

Outline of Final Research Achievements

The present study explored how ketone body metabolism in the central and liver (peripheral) respectively relates to sleep regulation. Experiments on suppression of HMGCS2 (ketone synthase) expression in the central and liver using siRNA oligos and establishment of HMGCS2 and SCOT (ketone degrading enzyme) expression regulating mice of neurons using the tet system were carried out. As a result, the possibility that the central HMGCS 2 is involved in the sleep-depth rebound after deprivation by handling and HMGCS 2 in the liver is involved in the sleep-depth rebound after treadmill exercise has come to light.

Free Research Field

環境生理学