Role of exercise-induced oncostatin M in the treatment of NASH

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Wakayama Medical University
• Principal Investigator: Morikawa Yoshihiro 和歌山県立医科大学, 医学部, 教授 (60230108)
• Co-Investigator(Renkei-kenkyūsha): KOMORI TADASUKE 和歌山県立医科大学, 医学部, 助教 (90433359) ; HISAOKA TOMOKO 和歌山県立医科大学, 医学部, 助教 (00398463) ; FURUTA HIROTO 和歌山県立医科大学, 医学部, 准教授 (90238684) ; MIYAJIMA ATSUSHI 東京大学, 分子細胞生物学研究所, 教授 (50135232)
• Research Collaborator: GYOBU HIROAKI
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病 / 非アルコール性脂肪肝 / サイトカイン / 運動

Outline of Final Research Achievements

In HFD-induced NASH model mice, intraperitoneal injection of OSM improved NASH as well as glucose intolerance, insulin resistance, and adipose tissue inflammation. OSM decreased food intake and intestinal lipid absorption, but did not affect on the body temperature and locomotor activity. In addition, the direct beneficial effects of OSM on lipid storage in hepatocytes were observed when OSM was injected into this model mice intraportally.
Swimming and moderate-intensity running induced the expression of OSM in the calf muscle, but not in the quadriceps. High-intensity running induced the expression of OSM in both the calf muscle and the quadriceps. The expression of OSMRβ was observed in the endothelial cells, satellite cells, and mesenchymal progenitor cells in the skeletal muscle, suggesting that exercise may exert the therapeutic effects on NASH through the action of exercise-induced OSM on these cells.

Free Research Field

神経内分泌学、代謝学、分子生物学