2017 Fiscal Year Annual Research Report
N-heterocyclic carbene-modified gold nanoparticles for biosensing
| Project/Area Number |
26288023
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| Research Institution | Nagoya University |
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Principal Investigator |
CRUDDEN Cathleen 名古屋大学, トランスフォーマティブ生命分子研究所, 客員教授 (10721029)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | Nano Material / Gold Nanoparticles / N-Heterocyclic Carbene / bidentate ligand / Stability / Bio-imaging |
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| Outline of Annual Research Achievements |
The goal of this grant was to prepare and test gold nanoparticles for potential biosensing applications. To address thiol-instability, we sought to increase stability by employing bidentate NHC ligands functionalized with long alkyl chains to block the surface. All nanoparticles prepared employing non-alkylated NHCs aggregated in solution within a week. By comparison, nanoparticles protected with alkylated NHCs survived heating to 130 C in xylene for 24 hrs.
All of the nanoparticles prepared by the top down approach provided more stable nanoparticles than those made with ligand exchange methods. The greater stability of nanoparticles prepared by the top-down method may be attributed to a higher NHC concentration on the surface. Regardless, this work represents the most stable NHC Au nanoparticles prepared to date and water-soluble versions are currently being prepared for use in vivo.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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