2017 Fiscal Year Final Research Report
Asymmetric C-H Bond Functionalization with Heterodinuclear Asymmetric Catalysts
| Project/Area Number |
26288043
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University (2015-2017)
The University of Tokyo (2014) |
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Principal Investigator |
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| Research Collaborator |
KATO Shota
KOJIMA Masahiro
TANAKA Ryo
IKEMOTO Hideya
SATAKE Shun
BUNNO Youka
SUN Bo
SUZUKI Yudai
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | C-H活性化 / 触媒 / 不斉触媒 / 脱水素 / 立体制御 / 複素環 |
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| Outline of Final Research Achievements |
We have succeeded in stereocontrol in catalytic carbon-hydrogen bond activation reactions by using newly developed catalysts. We also investigated new catalysts that enable control of radical reactive species. Although asymmetric variants have not yet been succeeded, we realized acceptor-less dehydrogenation of tetrahydronaphthalenes and indolines under visible light irradiation at ambient temperature. Finally, we also developed a new chiral heterodinuclear Schiff base catalyst for asymmetric allylic C-H bond functionalization. There still remain rooms for improvement in the enantioselectivity with the heterodinuclear catalyst, but the preliminary results in this study clearly indicated the utility of the present strategy.
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| Free Research Field |
合成化学
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