Development of Catalytic Methods for Construction of Stereogenic Centers through Bond Formation with Sterically Demanding sp3 Carbons

2016 Fiscal Year Final Research Report

• Project/Area Number: 26288048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Kyoto University
• Principal Investigator: Ohmura Toshimichi 京都大学, 工学(系)研究科(研究院), 准教授 (00378803)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 不斉化学合成 / 合成化学 / 有機ホウ素化合物 / 遷移金属触媒 / 触媒的分子変換

Outline of Final Research Achievements

The principle investigator established an efficient iridium catalyst system for conversion of sterically demanding C(sp3)-H bonds into C(sp3)-B bonds. He also found an iridium-catalyzed addition of C(sp3)-H bond across carbon-carbon multiple bonds, namely hydroalkylation. New insights into α-aminoalkylboron reagents in stereospecific Suzuki-Miyaura coupling, as well as in nucleophilic carbon-carbon bond formation mediated by alkali metal alkoxides, is obtained in the present study. These findings are valuable for rapid production of enantioenriched chiral molecules, which would innovate drug and functional material developments and researches involving chiral recognition.

Free Research Field

有機金属化学、有機合成化学