Targeting of cancer cells by protein nanospheres with high functions

2017 Fiscal Year Final Research Report

• Project/Area Number: 26289310
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Kobatake Eiry 東京工業大学, 生命理工学院, 教授 (00225484)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: タンパク質 / ナノ粒子 / DDS / 抗がん / 生体機能材料

Outline of Final Research Achievements

In this study, protein nanospheres were constructed for drug delivery system (DDS). Component proteins were consisting of hydrophobic thermo-responsive protein and poly-aspartic acids. This protein could be assembled and formed nanoapheres by mild heating. Molecular recognizing functional proteins could be displayed on the surface of nanospheres. On the other hand, hydrophobic anti-cancer drugs could be incorporated into the inside of nanospheres. These modified nanosphres could recognized cancer cells specifically, and kill cells by releasing anti-cancer drugs.

Free Research Field

タンパク質工学