2016 Fiscal Year Final Research Report
Molecular mechanisms of flexible decision making
| Project/Area Number |
26290008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Yamanashi (2016)
Juntendo University (2014-2015) |
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Principal Investigator |
UKA Takanori 山梨大学, 総合研究部, 教授 (50372933)
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| Research Collaborator |
SUDA Yuki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳・神経 |
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| Outline of Final Research Achievements |
Flexible decision making is a hallmark of human cognition. Subanesthetic dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, impairs such flexibility, but how it affects decision making circuits remains unclear. We recorded single unit activity in the lateral intraparietal area (LIP) while monkeys switched between a direction discrimination task and a depth discrimination task. Ketamine administration increased neural sensitivity to irrelevant information, and delayed the onset of decision-related neural activity. These results suggest that ketamine affected "what" information to process and "when" to process it.
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| Free Research Field |
神経生理学
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