2016 Fiscal Year Annual Research Report
Optogenetic countrol of visual perception
| Project/Area Number |
26290011
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
ベヌッチ アンドレア 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50722352)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Vision / animal cognition / decision making / optogenetics / fluorescent imaging / visual cortex / cortical plasticity |
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| Outline of Annual Research Achievements |
Progress on animal behavior: the behavioral setups for automated behavioral training of mice, with voluntary head-fixation have been augmented in high-throughput capacity, now training 50 animals/day. They have successfully allowed the collection of publishable behavioral data (manuscript under peer-review).Thanks to these setups we have trained animals in two visual-based discrimination tasks as part of ongoing projects aiming to examine the neural basis of animal’s decision-making, an important cognitive function for adaptive behaviors in complex environments.
Progress on neural recordings: last year’s preliminary work on calcium imaging recordings in the visual cortex of mice during optogenetic manipulations, has now matured to a publishable research project. Findings in such work have revealed that functional plasticity in recurrent neuronal networks can be induced solely by the activity of one or a very few neurons, and it can dramatically alter the stimulus selectivity of the whole network in a functionally predictable way, even outside juvenile developmental periods, in the cortex of adult animals. A manuscript summarizing these findings is in preparation.
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| Research Progress Status |
28年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
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| Causes of Carryover |
28年度が最終年度であるため、記入しない。
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| Expenditure Plan for Carryover Budget |
28年度が最終年度であるため、記入しない。
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| Remarks |
I believe the patent has been approved by RIKEN and under review at the Japan patent office
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Research Products
(2 results)
