2016 Fiscal Year Final Research Report
Mitochondrial dynamics in mammals and its molecular mechanism
Project/Area Number |
26291032
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biophysics
|
Research Institution | Kyushu University |
Principal Investigator |
Koshiba Takumi 九州大学, 理学(系)研究科(研究院), 准教授 (70403970)
|
Co-Investigator(Kenkyū-buntansha) |
渡邊 利雄 奈良女子大学, 自然科学系, 教授 (60201208)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | ミトコンドリア / 分子機構 / 抗ウイルス自然免疫 |
Outline of Final Research Achievements |
Mitochondria are dynamic organelles that undergo cycles of homotypic fusion and fission events, which are believed to play an important role in biologic process. Although the importance of mitochondrial dynamics is well documented, the molecular mechanism remain unclear. Our aims of the project is to elucidate their knowledges of mitochondrial dynamics, and try to understand the mechanism at molecular level. In this project, (1) we generated mice deficient in molecules involved in mitochondrial dynamics, and also (2) we investigated relationship between mitochondrial dynamics and antiviral innate immunity in vitro.
|
Free Research Field |
生物物理学
|