2016 Fiscal Year Final Research Report
Molecular mechnisms underlying the layer and column specific target recongnition in the visual system axons
Project/Area Number |
26291047
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
Suzuki Takashi 東京工業大学, 生命理工学院, 准教授 (60612760)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 神経遺伝学 / ショウジョウバエ / 軸索投射 / 受容体型膜タンパク質 / 軸索間相互作用 |
Outline of Final Research Achievements |
A detailed functional analysis of fmi mutant in the pupal stages revealed that the Fmi promotes the extension of filopodia and that Gogo has a function to antagonize that effect. This supressive function of Gogo helps the R8 axons to maintain their distance and prevent them from bundling. In the later half of the pupal stage, when Gogo expression become down regulated, filopodia extension promoted by Fmi takes place. These data suggest that Gogo function to suppress the filopodia extension contributes to shape the axonal array with a constant distance among axons at the surface of the target ganglion.
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Free Research Field |
神経生物学
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