Researches for the pathogenesis and disease models of canine degenerative myelopathy, leptomeningeal histiocytic sarcoma, and multiple myositis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26292157
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: UCHIDA Kazuyuki 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10223554)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: コーギー犬 / 組織球性肉腫 / Cell line / 樹状細胞 / マクロファージ / ランゲルハンス細胞 / 変性性脊髄症 / 筋疾患

Outline of Final Research Achievements

The present study revealed the pathological features of breed specific diseases occurring in Pembroke Welsh Corgi(PWC) dogs, especially histiocytic sarcoma and degenerative myelopathy. Regarding histiocytic sarcomas, cell line derived from leptomeningealhistiocytic sarcomas in a PWC dog was established. Two additional cell lines from synovial histiocytic sarcoma of a flat-coated retriever dog and canine cutaneous Langerhans cell histiocytosis have been successfully established. These three types of cell lines will be exellent tools for the basic researches on tumoregenesis and therapeutic drug development on histiocytic sarcomas, not only in dogs but also in humans. Regarding canine degenerative myelopathy, autophagy abnormality is involved in addition to SOD1 mutation in PWC dogs.

Free Research Field

獣医病理学