A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293070
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Juntendo University
• Principal Investigator: Imai Yuzuru 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (30321730)
• Co-Investigator(Kenkyū-buntansha): 井下 強 順天堂大学, 医学(系)研究科(研究院), 助教 (20601206) ; 柴 佳保里 順天堂大学, 医学(系)研究科(研究院), 准教授 (30468582)
• Co-Investigator(Renkei-kenkyūsha): SHIBA Kahori (福嶋 佳保里) 順天堂大学, 医学研究科, 准教授 (30468582) ; INOSHITA Tsuyoshi 順天堂大学, 医学研究科, 助教 (20601206) ; HATTORI Nobutaka 順天堂大学, 医学部, 教授 (80218510)
• Research Collaborator: MENG Hongrui 順天堂大学, 医学研究科, 研究員 (90736498) ; ARANO Taku 順天堂大学, 医学研究科, 研究員 (80750091) ; ISHIHAMA Yasushi 京都大学, 薬学研究科, 教授 (30439244)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ミトコンドリア / ドーパミン神経 / iPS細胞 / リン酸化

Outline of Final Research Achievements

The genes for autosomal recessive early-onset Parkinson’s disease, Parkin and PINK1 have been suggested to regulate mitochondrial quality control while the autosomal dominant late-onset Parkinson’s disease gene, CHCHD2, encodes a mitochondrial protein with unknown functions. In this study, we examined the molecular mechanism of the PINK1-Parkin signaling, the molecular functions of CHCHD2 and the relationship between the PINK1-Parkin signaling and CHCHD2 using Drosophila models, iPS cells and mammalian cultured cells.

Free Research Field

神経科学