Prevention of diabetic vascular injury and atherosclerosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293152
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Okayama University
• Principal Investigator: Ogino Keiki 岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)
• Co-Investigator(Kenkyū-buntansha): 長岡 憲次郎 岡山大学, 医歯(薬)学総合研究科, 助教 (40752374) ; 杉山 斉 岡山大学, 医歯(薬)学総合研究科, 教授 (60325090) ; 久保 正幸 岡山大学, 医歯(薬)学総合研究科, 助教 (60420519) ; 江口 依里 岡山大学, 医歯(薬)学総合研究科, 助教 (60635118) ; 竹本 圭 岡山大学, 医歯(薬)学総合研究科, 助教 (60723252)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルギナーゼ / NO / アルギニン / 喘息 / 酸化ストレスマーカー

Outline of Final Research Achievements

In asthma, serum arginase I was augmented in human study and experimental mice model. Elevated serum arginase I derived from inflammatory lung reduced L-arginine levels and reduced NO generation in bronchial smooth muscle. Moreover, serum arginase I was positively associated with 8-OHdG, a biomarker of oxidative stress and negatively associated with L-arginine. Therefore, serum arginase I may assocated with atherosclerosis by regulating serum L-aginine levels and NO in vascular endothelial cells.

Free Research Field

分子予防医学