Analysis of the mechanism of homeostatic maintenance against Alzheimer's disease and its failure due to diabetes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293167
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: National Center for Geriatrics and Gerontology (2016); Osaka University (2014-2015)
• Principal Investigator: SATO Naoyuki 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 部長 (70372612)
• Co-Investigator(Kenkyū-buntansha): 田中 稔久 大阪大学, 医学(系)研究科(研究院), 准教授 (10294068) ; 村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 神経内科, 部長 (50183653) ; 宮崎 早月 大阪大学, 医学(系)研究科(研究院), 助教 (60452439) ; 内尾 こずえ 国立研究開発法人医薬基盤・健康・栄養研究所, 疾患モデル小動物研究室, 主任研究員 (70373397) ; 上田 裕紀 大阪大学, 医学(系)研究科(研究院), 招へい研究員 (90543463)
• Co-Investigator(Renkei-kenkyūsha): IKEUCHI Takeshi 新潟大学, 脳研究所, 教授 (20372469) ; TAKEYA Yasushi 大阪大学, 大学院医学系研究科, 助教 (70590339)
• Research Collaborator: TAKEYA Miyuki ; MUKOUZONO Masahiro
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖尿病 / 認知症 / 遺伝子

Outline of Final Research Achievements

Diabetes is known to be one of the risk factors for Alzheimer's disease (AD). β-amyloid is considered to be causative for AD. This study revealed the biological response to β-amyloid at the molecular level. The biological response to β-amyloid may contribute to homeostatic maintenance against AD. Furthermore, it was revealed that the biological response to β-amyloid failed due to diabetes. These results would lead to the development of therapeutic options for dementia.

Free Research Field

老年医学