2016 Fiscal Year Final Research Report
Epigenetic regulation of stress vulnelability
| Project/Area Number |
26293169
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑野 由紀 徳島大学, 大学院医歯薬学研究部, 助教 (00563454)
井本 逸勢 徳島大学, 大学院医歯薬学研究部, 教授 (30258610)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ストレス脆弱性 / エピジェネテイックス / 非コードRNA / DNAメチル化 / RNA結合タンパク質 |
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| Outline of Final Research Achievements |
Distinct microRNAs are suggested to play a potential role in stress coping. Long non-coding RNAs and chromatin-binding proteins are also important epigenetic regulators. This study was designed to reveal a possible link between the vulnerability of stress and epigenetic regulators. First, we could show that a group of genes related to eukaryotic initiation factor 2 (EIF2)-dependent signals were potential biomarkers for chronic psychological stress in healthy young adults and IBS patients. We succeeded to identify stress microRNA markers in a group of people under distressed conditions and chronic fatigue syndrome-associated microRNAs in peripheral blood. We identified TRA2beta 4 RNA as a new long non-coding RNA facilitating oxidative stress-associated, mitogen responses. We also showed that homeodomain-interacting protein kinase 2, a DNA damage-responsive kinase, participates in the regulation of dynamic interaction between HP1gamma and histone H3K9me3 to promote DNA repair.
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| Free Research Field |
ストレス科学
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