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2016 Fiscal Year Final Research Report

Inorganic phosphate balance in cerebrospinal fluid and hyperphosphatemia

Research Project

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Project/Area Number 26293204
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

MIYAMOTO Kenichi  徳島大学, 大学院医歯薬学研究部, 教授 (70174208)

Co-Investigator(Kenkyū-buntansha) 瀬川 博子  徳島大学, 大学院医歯薬学研究部, 講師 (70325257)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords唾液 / 腎臓 / リン / 慢性腎臓病 / トランスポーター
Outline of Final Research Achievements

Cerebrospinal fluid (CSF) inorganic phosphate (Pi) may regulate a central NaPi transporter expression and transduce signals to initiate the appetitive behavior and saliva Pi adaptations. However, the regulation of salivary Pi concentration remains unknown. In the salivary gland duct cell, Npt2b is localized and regulates the concentration of salivary Pi concentrations. Salivary Pi levels are controlled by dietary phosphorus contents and Npt2b is undergoing rapid regulation. In addition, in the chronic kidney disease (CKD) model, salivary Pi concentrations were significantly increased in Npt2b (-/+) mice compared with those in Npt2b (+/+) mice. In conclusion, Npt2b in the salivary glands may be important molecule for Pi homeostasis as well as Npt2a in the kidney.

Free Research Field

内科臨床医学・腎臓内科学

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Published: 2018-03-22  

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