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2016 Fiscal Year Final Research Report

Vaspin and its interacting molecules as therapeutic targets for metabolic syndrome

Research Project

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Project/Area Number 26293218
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Metabolomics
Research InstitutionOkayama University

Principal Investigator

Wada Jun  岡山大学, 医歯(薬)学総合研究科, 教授 (30294408)

Research Collaborator NAKATSUKA Atsuko  岡山大学病院, 腎臓・糖尿病・内分泌内科, 助教 (00625949)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsメタボリックシンドローム / アディポカイン / セリンプロテアーゼ / 小胞体ストレス / 肥満症
Outline of Final Research Achievements

We identified vaspin (visceral adipose tissue-derived serine protease inhibitor) as a novel adlipokine. Vaspin inhibits insulin resistance, fatty liver, dyslipidemia and atherosclerosis in metabolic syndrome. Vaspin inhibits kallikrein 7 belonging to serine protease and increases glucagon-like peptide-1. We generated DNAJC1 (DnaJ homolog, subfamily C, member 1) conditional knockout mice and we demonstrated that they are therapeutic targets for metabolic syndrome.

Free Research Field

内科学、糖尿病学、腎臓病学、肥満症、メタボリックシンドローム

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Published: 2018-03-22  

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