2016 Fiscal Year Final Research Report
Innate immunity in the pathogenesis of rheumatoid arthritis
| Project/Area Number |
26293235
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
Hajime Kono 帝京大学, 医学部, 准教授 (60585074)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
南木 敏宏 帝京大学, 医学部, 准教授 (00282749)
関根 知世子 帝京大学, 医学部, 助教 (40392005)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | インフラマソーム |
|---|
| Outline of Final Research Achievements |
IL-1 plays important role in the pathogenesis of rheumatoid arthritis or other sterile inflammation. IL-1 activation is mediated by inflammasome activation. We have developed an cell based assay to visualize inflammasome activation. By utilizing a genome-wide expression library, we identified several genes that activate or suppress inflammasome activation.
|
| Free Research Field |
臨床免疫学
|
