2016 Fiscal Year Final Research Report
Association analysis between classical HLA and schizophrenia
| Project/Area Number |
26293266
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Fujita Health University |
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Principal Investigator |
Ikeda Masashi 藤田保健衛生大学, 医学部, 准教授 (60424933)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 臨床精神分子遺伝学 |
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| Outline of Final Research Achievements |
MHC region including HLA is promising candidate region for schizophrenia based on genome-wide association studies (GWASs). In this study, we focused on the classical HLA, and conducted association analysis using relatively large sample size (2500 schizophrenia and 3000 controls in the Japanese population). However, we could not detect significant association between specific HLA allele and schizophrenia.
In summary we speculate that the GWAS signal in the MHC region may not point the classical HLA, but non-HLA genes as risk genes for schizophrenia.
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| Free Research Field |
医歯薬学
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