Induction of tolerance by rejuvenation of thymus in preclinical large animal model.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293292
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Nobori Shuji 京都府立医科大学, 医学(系)研究科(研究院), 講師 (30433288)
• Co-Investigator(Kenkyū-buntansha): 山田 和彦 鹿児島大学, 医用ミニブタ・先端医療開発研究センター 臓器置換・異種移植外科分野, 教授 (40241103) ; 佐原 寿史 鹿児島大学, 医用ミニブタ・先端医療開発研究センター 臓器置換・異種移植外科分野, 准教授 (90452333)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 移植・再生 / 前臨床研究 / 免疫寛容 / 胸腺 / ミニブタ

Outline of Final Research Achievements

Our previous study suggested that rejuvenation of thymus and bone marrow from juvenile donors have important role of inducing transplant tolerance. Expression of IGF1R in thymus can be the marker of transplant tolerance. However, the important question remained whether aged, involuted thymus could also induce tolerance. We tested the IGF level in aged swine thymus after transplantation of aged thymus from aged donor. It showed rejection in aged thymus and sensitization against the donor.

Free Research Field

移植免疫