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2016 Fiscal Year Final Research Report

Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing

Research Project

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Project/Area Number 26293304
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

IMOTO Issei  徳島大学, 大学院医歯薬学研究部, 教授 (30258610)

Co-Investigator(Kenkyū-buntansha) 丹黒 章  徳島大学, 大学院医歯薬学研究部, 教授 (10197593)
高山 哲治  徳島大学, 大学院医歯薬学研究部, 教授 (10284994)
Co-Investigator(Renkei-kenkyūsha) YANAGAWA Hiroaki  徳島大学, 病院, 准教授 (50263827)
OTSUJI Eigo  京都府立医科大学, 医学(系)研究科, 教授 (20244600)
TAJIMA Atsushi  徳島大学, 大学院医歯薬学研究部, 准教授 (10396864)
MASUDA Kiyoshi  徳島大学, 大学院医歯薬学研究部, 准教授 (00457318)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsゲノム / オミックス / 分子プロファイリング / ゲノム編集 / 食道癌 / シミュレーション
Outline of Final Research Achievements

To optimize therapeutic strategy overcoming the therapy resistance, recurrence, and metastasis for realizing the personalized medicine in patients with ESCC, we have detected intratumoral heterogeneity and estimated the clonal structure and its association with functional features of tumor based on the simulation by omics data modeling using tumors and plasma DNAs and experimental validation using genome editing technology. Novel molecular targets for ESCC were identified using integrated data. In addition, we have developed highly efficient mutation-introducing methods into cell lines using Crispr/Cas9 system, selected mutated clones by various reagents including anti-cancer reagents, and determined the pattern of mutations necessary for the therapy resistance in ESCC.

Free Research Field

ゲノム医科学

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Published: 2018-03-22  

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