The role of bone marrow-derived CD11b positive cells in recurrence of oral cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293431
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: KIOI Mitomu 横浜市立大学, 医学部, 准教授 (30545059)
• Co-Investigator(Kenkyū-buntansha): 藤内 祝 横浜市立大学, 医学研究科, 教授 (50172127) ; 谷口 英樹 横浜市立大学, 医学研究科, 教授 (70292555)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: がん微小環境

Outline of Final Research Achievements

In the present study, we investigated the role of infiltrating CD11b+ myeloid cells in the vascularization and recurrence of oral squamous cell carcinoma (OSCC). In a xenograft mouse model, local irradiation caused vascular damage and hypoxia in the tumor and increased infiltration of CD11b+ myeloid cells. These infiltrating cells showed characteristics of M2 macrophages (M2Mφs) and are associated with the promotion of vascularization. M2Mφs promoted tumor progression in recurrence after irradiation. In addition, we found that CD11b+ myeloid cells, as well as CD206+ M2Mφs, are increased during recurrence after radiotherapy in human OSCC specimens. Our findings indicate that polarization of M2Mφs derived from recruited CD11b+ cells into tumor after irradiation contributes vascularization leading to recurrence of OSCC.

Free Research Field

口腔癌