Investigation for metabolic features in divergency of ageing

2016 Fiscal Year Final Research Report

• Project/Area Number: 26310103
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 特設分野
• Research Field: Neo-Gerontology
• Research Institution: Kyoto University
• Principal Investigator: Kondoh Hirohsi 京都大学, 医学(系)研究科(研究院), 准教授 (80402890)
• Co-Investigator(Kenkyū-buntansha): 横出 正之 京都大学, 医学(系)研究科(研究院), 教授 (20252447) ; 高折 晃史 京都大学, 医学(系)研究科(研究院), 教授 (20324626)
• Project Period (FY): 2014-07-18 – 2017-03-31
• Keywords: 老化 / 代謝

Outline of Final Research Achievements

Enhanced glycolysis, the Warburg effect, is well-known property of cancer, while it is not clear how it is coupled with the other hallmark of cancer, immortalization. Several recent reports established the significance of phosphoglycerate mutase PGAM both in the Warburg effect and cancerous proliferation. Moreover, the recent analysis of PGAM-TG and KO mice disclosed the impact of PGAM on the Warburg effect. Interestingly, cooperative manner are observed on the impact of PGAM in vivo and in vitro. Ｗe develop standard experimental procedures to identify and precisely quantify human age-related blood metabolites. To this end, our intent was to increase the reproducibility and accuracy of measuring blood metabolites, which are highly unstable. The combination of comprehensive CV (coefficient of variation) analysis and RBC (red blood cell) metabolomics enabled us to identify 51 previously unreported metabolite CVs. Ultimately, we identified 14 age-related metabolites.

Free Research Field

老化生物学