Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems

2017 Fiscal Year Final Research Report

• Project/Area Number: 26310204
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 特設分野
• Research Field: Mathematical Sciences in Search of New Cooperation
• Research Institution: Tohoku University
• Principal Investigator: Hayashi Kumiko 東北大学, 工学研究科, 助教 (00585979)
• Co-Investigator(Kenkyū-buntansha): 丹羽 伸介 東北大学, 学際科学フロンティア研究所, 助教 (30714985) ; 池田 一穂 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (20642565) ; 岡田 康志 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (50272430)
• Project Period (FY): 2014-07-18 – 2018-03-31
• Keywords: 非平衡統計力学 / 分子モーター / 医療

Outline of Final Research Achievements

Organelle transport by kinesin and dynein is deeply related to medical and cosmetic issues. For example, deficit of the transport is a problem as to Alzheimer disease, and melanin pigment produced by sunburn is also transported by kinesin and dynein as melanosomes. The theorems of non-equilibrium statistical mechanics were applied to the in vivo transport because the transport was represented by non-equilibrium stochastic processes. Concretely, we investigated synaptic vesicle precursor transport and melanosome transport. The physical reasons of mis-location of synapses and the effect of dynein inhibitor called ciliobrevin on force and number of motors were clarified.

Free Research Field

非平衡統計力学