2016 Fiscal Year Final Research Report
Impact of exercise and serum Myostatin associated with muscle wasting in patients with heart failure
Project/Area Number |
26350590
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 慢性心不全 / 運動耐耐容認能力 / 嫌気性代謝域値 / ミオスタチン |
Outline of Final Research Achievements |
Back ground: It is still unknown that adequate exercise prescription of aerobic and low grade resistance training in patients with moderate symptom of heart failure. The Aim of this study is to clarify additional low grade resistance training intervention to usual aerobic exercise including the change of some biomarkers associated muscle wasting.Method; 28patients were initially randomized to usual training group(n=13) and additional resistance training group(n=15).Result: There was no significant difference between 2 groups at the baseline characteristics. The change ratio in Anaearobic threshold(AT) in additional training group was significant higher than that of usual training group. There were not significant difference in Peak VO2 as well as serum concentration of Myostain ,BDNF between groups. Conclusion : Additional low grade resistance training may lead to improve the AT in patients with moderate heart failure. However, we could not find the improvement of biomarkers
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Free Research Field |
リハビリテーション学
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