Investigation of swallowing dysfunction after sensory stimulation in experimental animal models

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350649
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: Kano Mitsuhiro 東北大学, 歯学研究科, 大学院非常勤講師 (10419236)
• Co-Investigator(Renkei-kenkyūsha): ICHIKAWA HIROYUKI 東北大学, 大学院歯学研究科, 教授 (20193435)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 摂食嚥下 / リハビリテーション

Outline of Final Research Achievements

Immunohistochemistry for PGP 9.5, CGRP, TRP channes was performed on the rat and mouse soft palate, epiglottis and pharynx. Motor nerve　endings contained PGP 9.5 and CGRP, whereas Sensory nerve endings contained CGRP, TRPV1 and TRPM8. CGRP-containing motor endplates and CGRP-immunoreactive density were increased in oral, pharyngeal and laryngeal muscles of dmu mice.  In a laryngeal muscle, the atrophy of muscle fibers could be detected and the density of cell nuclei in the musculature increased.  However, distribution of TRPV1 and TRPM8 was similar in wild type and dmu mice.  Distributional change of PGP 9.5, CGRP, TRP channels was obscure in ALS models and model animals of aging. Transection of vagal and glossopharyngeal nerves decreased the number of motor and sensory nerve fibers.  Degeneration of sensory and motor nerve fibers soft palate, epiglottis and pharynx may be associated with swallowing dysfunction in experimental animals.

Free Research Field

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