Role of unfolded protein response on age-related skeletal muscle atrophy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MIYAKE Masato 徳島大学, 先端酵素学研究所(プロテオ), 助教 (30588976)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 小胞体 / 小胞体ストレス / 骨格筋 / 萎縮 / アミノ酸

Outline of Final Research Achievements

Unfolded protein response (UPR) is one of signal transduction pathway activated in　endoplasmic reticulum (ER) respond to accumulation of unfolded proteins in ER lumen. In　this study, we found that UPR is more activated in skeletal muscle of old mice than young　mice. To understand the role of PERK pathway, one of the UPR signaling, we generated　transgenic mouse that enable to control PERK signaling pathway This transgenic mouse　showed muscle atrophy in young age after activation of PERK. Skeletal muscle of the　transgenic mouse changed the amino acid metabolism compared with wild type mouse,　especially branched-chain amino acids and anti-oxidant amino compounds. Overall, this　study suggests that unfolded response modulate age-related skeletal muscle atrophy or　sarcopenia.

Free Research Field

筋細胞生物学