2016 Fiscal Year Final Research Report
Exercise promotes homeostatic control and post-injury regeneration by altering stem cell niche
Project/Area Number |
26350918
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
|
Research Institution | Kindai University |
Principal Investigator |
NIWA Atsuko 近畿大学, 医学部, 講師 (60122082)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 脳血管障害 / 運動 / 血管内皮前駆細胞 / 神経新生 / 第3脳室(視床下部) / 骨髄 / 微小環境(ニッチ) / 恒常性 |
Outline of Final Research Achievements |
Beneficial effects of exercise (EX) in the hypothalamus and bone marrow (BM)were examined for homeostasis and regeneration. A neural progenitor cell, tanycytes, proliferated, differentiated, and matured to NeuN+ neuron in the hypothalamus of adult SHRSP. EX activated tanycytes and promoted cell turn over. Neurogenesis may require FGF-2 and EGF production in adult hypothalamus, and restore physiological and neural functions effectively after stroke in EX SHRSP. Myeloid cell ratio was increased with progression of cerebrovascular disease and that was normalized by EX. Stroke injury induced dynamic fluctuation in SDF-1 distribution that correlated with variations in niche occupation of CD34+/c-kit+ angiogenic stem/progenitor cells. Stem cell niches (SDF-1) in EX responded to injury-related cues that mobilized CD34+ cells from endosteal niche after stroke to sinusoidal vascular niche, which promoted the progenitor proliferation. EX improves the mobilization and activation of BM stem cells.
|
Free Research Field |
薬理学
|