2017 Fiscal Year Final Research Report
The role of neuronal diversity in the neural circuit of somatosensory cortex
| Project/Area Number |
26350980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 神経細胞 / 多様性 / 神経回路形成 |
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| Outline of Final Research Achievements |
Using several c-Pcdh deletion mutant and conditional knockout（cKO） mouse lines, I investigated the role of c-Pcdh in the somatosensory cortical barrel formation. Pcdh-alpha, Pcdh-beta and Pcdh-alpha-beta deletion mutant mice showed normal barrel formation. Pcdh-gamma deletion mutant mice died within 24h after birth. I analyzed Pcdh-gamma cKO mice and found that obscure barrel formation. Based on these results, I generated c-Pcdh gene modified mouse using CRISPR/Cas9 system.
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| Free Research Field |
神経科学 ゲノム科学
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