2017 Fiscal Year Final Research Report
Roles of SCD, an enzyme for unsaturated fatty acid synthesis, in the early lesion of Alzheimer''s model mice.
| Project/Area Number |
26350984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
Song Si-Young 徳島文理大学, 大学共同利用機関等の部局等, 教授 (00399693)
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| Co-Investigator(Kenkyū-buntansha) |
中島 健太郎 徳島文理大学, 大学共同利用機関等の部局等, 助手 (20449911)
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| Research Collaborator |
安達 栄治郎 北里大学, 医療系研究科・細胞組織再生医学
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | SCD / アルツハイマー病 / 病態モデルマウス / 樹状突起 / シナプス / 免疫組織化学 / laser microdissection |
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| Outline of Final Research Achievements |
Analyses by immunohistochemistry, in situ hybridization and real-time PCR revealed SCD2 dominant, rather than SCD1, expression was detected in neurons of mice. SCD-immunoreactivity (IR) tends to distribute in thin dendritic processes showing fine granular patterns during postnatal development, but increased SCD-IR was detected in 3 x Tg AD mice as compared with wild type mice at postnatal six months, showing coarse granular and segmental distribution in dendrites. Relatively large spines, swollen like a bead, were observed along dendrite and synaptobrevin-IR was decreased. These findings suggest the possibility that early lesions of AD appear in dendrite of the hippocampus and SCD is involved in the processes
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| Free Research Field |
実験神経病理学
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