Mechanism of emotional formation by enriched environment in early life of ADHD model animal

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Nagoya City University
• Principal Investigator: HIDA HIDEKI 名古屋市立大学, 大学院医学研究科, 教授 (00305525)
• Co-Investigator(Renkei-kenkyūsha): MISUMI SACHIYO 名古屋市立大学, 大学院医学研究科, 助教 (70529148) ; ISHIDA AKIMASA 名古屋市立大学, 大学院医学研究科, 助教 (20632607)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 情動 / 発育期 / うま味 / グルタミン酸ナトリウム / 腸脳連関 / 脳血液関門培養モデル / 胃迷走神経

Outline of Final Research Achievements

Using spontaneously hypertensive rat, the change of emotional behavior by monosodium glutamate (MSG) intake during the period of development was investigated. MSG ingestion resulted in a significant reduction in aggressive behavior. To know the mechanism in less aggression, several experiments were performed as follows. Blood pressure was comparable to the controls. Argyrophil III staining to detect neuronal damage revealed no evidence of injury in the aggression-related brain areas. Assessment of plasma amino acids revealed a transient increase of the ingestion after fasting. However, lactate dehydrogenase assay in blood–brain barrier in vitro model showed that cell toxicity was not induced by indirect MSG application even at 700 microM. The vagotomy at sub-diaphragm level indicated that aggressive behavior is mediated by vagus nerve. Data suggest that MSG ingestion during the period of development could reduce aggressive behavior, mediated by gut-brain interaction.

Free Research Field

脳神経生理学