2016 Fiscal Year Final Research Report
The physiological functions of a C-type lectin receptor and the relation with diseases
Project/Area Number |
26430095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Tohoku Medical and Pharmaceutical University (2016) Tokyo University of Science (2014-2015) |
Principal Investigator |
KAIFU Tomonori 東北医科薬科大学, 医学部, 講師 (90343037)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | C型レクチン受容体 / DCIR |
Outline of Final Research Achievements |
Dendritic Cell ImmunoReceptor(DCIR) is an inhibitory type of C-type lectin receptor and the functional defect of DCIR leads to disturbance of maintaining the homeostasis of the immune system. As Dcir-deficient mice spontaneously developed autoimmune-like diseases and were susceptible for some of experimental animal disease models, DCIR is involved in the pathogenesis of a sort of disease. Therefore, we evaluated the role of DCIR in a chronic inflammatory disorder. Moreover, we attempted to generate a tool of analyzing the function of an additional C-type lectin receptor.
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Free Research Field |
実験動物学
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