2016 Fiscal Year Final Research Report
The elucidation of function of long noncoding RNAs induced by oncogenic signal and the exploration of their inhibitors.
| Project/Area Number |
26430127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ガン化シグナル / 長鎖ノンコーディングRNA / 細胞周期 |
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| Outline of Final Research Achievements |
In this study, we revealed that a long noncoding RNA, PANDA, induced by oncogenic signal stabilizes p53 tumor suppressor protein in response to DNA damage. Quantitative RT-PCR assay showed that PANDA was highly expressed in U2OS human osteosarcoma cells. Silencing PANDA caused arrest at the G1 phase of the cell cycle, leading to inhibition of cell proliferation. We revealed that PANDA promotes G1-S transition by repressing p18 transcription, and thus promotes U2OS cell proliferation. These results indicate that PANDA may be a good molecular target for cancer treatment drug.
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| Free Research Field |
腫瘍生物学
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