2016 Fiscal Year Final Research Report
Exploration and evaluation of carbohydrate tumor marker
Project/Area Number |
26430151
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
|
Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
Principal Investigator |
MIYAMOTO Yasuhide 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 総括研究員(分子生物学部門長) (90322742)
|
Research Collaborator |
Okamoto Miki 地方独立行政法人大阪府立病院機構, 大阪府立成人病センター(研究所)・その他の部局, 研究員 (20332455)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 糖鎖 / 腫瘍マーカー |
Outline of Final Research Achievements |
We have attempted to identify a novel glycan tumor marker by comparing the serum O-glycan profiles from healthy controls with those of cancer patients. We identified 3 marker candidates. The precise oligosaccharide structures of these candidates was clarified. To quantify these glycans, we developed the selected reaction monitoring (SRM) assay, which used a stable isotope-labeled glycan as internal standard with a high level of sensitivity and accuracy. Verification study of one of the candidate was then performed by SRM analyses.
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Free Research Field |
腫瘍生化学
|